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KMID : 1161420230260050319
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Journal of Medicinal Food
2023 Volume.26 No. 5 p.319 ~ p.327
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Dose?Response Evaluation of Scopoletin, a Phytochemical, in a High-Fructose High-Fat Diet-Induced Dyslipidemia Model in Wistar Rats
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Gurpreet Kaur Batra
Chakrant Mothsara
Swati Sharma
Aishwarya Anand
Alka Bhatia
Shobhit Bhansali
Sant Ram
Arnab Pal
Amol N. Patil
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Abstract
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The putative hypolipidemic properties of scopoletin have not been fully confirmed due to a lack of validation in an irreversible chronic hyperlipidemia animal model. The druggability also needs to be studied in terms of bioavailability in the vascular compartment. Accordingly, we conducted a study to assess the hypolipidemic and pharmacokinetic behavior of scopoletin in the high-fructose high-fat diet (HFHFD)-induced dyslipidemia model in Wistar rats. A total of 42 rats were studied, with 6 in each of the 7 groups. A 60-day HFHFD opted for induction of dyslipidemia. Group I and groups II?VII received normal rat chow diet and HFHFD, respectively. Oral scopoletin (1, 5, 10?mg/kg) and atorvastatin 5?mg/kg were administered in groups III?VI, respectively, once daily for the next 15 days. A separate group, group VII, was used for the pharmacokinetic assessment comparing the scopoletin 10?mg/kg intraperitoneally (IP) in group VII versus the oral (group V). Pharmacokinetic blood sampling was performed on the 10th day of continuous once-daily therapy. Rats were sacrificed for the histological examination. All three scopoletin dosages significantly decreased the total cholesterol, low-density lipoproteins, and triglycerides (P?
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KEYWORD
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Ayurveda, high-fructose high-fat diet, hypolipidemic, Indian traditional medicine, pharmacokinetics, phytochemical, scopoletin
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